Ibuprofen tablets may be well tolerated in some patients who have had gastrointestinal side effects with aspirin, but these patients when treated with ibuprofen tablets should be carefully followed for signs and symptoms of gastrointestinal ulceration and bleeding. Ibuprofen can increase your risk of fatal heart attack or stroke. Do not use this medicine just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Ibuprofen may also cause stomach or intestinal bleeding, which can be fatal. The NHS advises that you should not take ibuprofen orally or apply it to your skin if you have ever had an allergic reaction or symptoms like wheezing, a runny nose or a skin reaction after. People who take nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as ibuprofen may have a higher risk of having a heart attack or a stroke than people who do not take these medications. These events may happen without warning and may cause death. Ibuprofen can interact with a variety of medications, supplements, and substances, potentially causing serious side effects or reducing effectiveness. Common interactions include blood thinners, lithium, certain blood pressure medications, and other NSAIDs. Most adults can use ibuprofen. But ibuprofen is not suitable for everyone. For example, it may not be suitable if: Check the packet or leaflet that comes with your medicine to see if it's suitable for you. Don’t take more than 1,200 milligrams of ibuprofen a day, unless directed by a provider. If you need it longer than 10 days, seek medical attention. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis), such as inflammation, swelling, stiffness, and joint pain. View ibuprofen information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, contra-indications and important safety information. Severe heart failure and severe kidney disease are contraindications, as ibuprofen can worsen these conditions by increasing fluid retention and reducing renal function.